Why drug makers share their prized compound libraries with competitors

first_img Pharmaceutical companies amass huge libraries of chemical compounds they can test to see if one just might be capable of being developed into a new drug. But what if, even with millions of compounds, you’re missing some that could lead to your next blockbuster treatment?That was the idea behind Friday’s announcement that AstraZeneca and Sanofi will swap 210,000 compounds from their libraries, giving each company new compounds to screen. (It’s worth noting, as STAT Pharmalot Ed Silverman columnist points out, “the move comes as both companies struggle to replenish their product portfolios and appease restive shareholders.”)Companies measure the potential of the compounds through a process called high-throughput screening, in which the compounds are tested on different cells or molecules to see if they are a “hit” for a certain disease target. If there is a hit, scientists work to refine the compound and then start testing it in animal models to explore if it could eventually provide the foundation for a new drug. It takes years even if all goes well, but it’s one key way that drugs are discovered. (Companies also try to design compounds specifically for certain disease targets instead of doing the mass testing that this type of screening requires.)advertisement About the Author Reprints Pharmaceutical companies amass huge libraries of chemical compounds they can test to see if one just might be capable of being developed into a new drug. By Andrew Joseph Nov. 20, 2015 Reprints @DrewQJoseph Tags AstraZenecadrug developmentSanofi AstraZeneca has shared before with industryAbout four years ago, AstraZeneca and Bayer opened up their libraries to each other, but they only screened the compounds on targets that were not relevant to the other company. (In the AstraZeneca-Sanofi deal, no restrictions were placed on the screening.) One interesting discovery: Scientists from AstraZeneca and Bayer reported in Drug Discovery Today in 2012 that there was little overlap between the two collections, concluding that “one can effectively access a large collection of additional, diverse, high-quality and well-kept screening compounds … [in] the screening collection of a competing pharmaceutical company.”…and with academiaLast year, AstraZeneca launched a partnership with the Academic Drug Discovery Consortium, a network of more than 130 academic drug discovery centers formed in 2012. The consortium does not have its own compound library, and academic institutions may only have a few thousand compounds in their libraries. With the partnership, selected researchers get access to 250,000 of AstraZeneca’s compounds. The compounds are sent to the scientists, who perform the screening on targets they develop. For researchers, the program opens the door to a wealth of compounds, and for AstraZeneca, the company typically gets the first chance to license any promising technology. “A lot of the biology expertise and knowledge about the genes and the disease, that comes largely from academia,” said Matthew Hartman, secretary and treasurer of the consortium.Biotech and pharma will partner with the government as wellRobots at the National Center for Advancing Translational Sciences, an arm of the National Institutes of Health, perform 3 million tests a week of roughly 500,000 compounds on different disease targets. The scientists there regularly work with biotechnology companies who want to study how certain disease targets respond to certain compounds. “They may not have the chemical libraries, they may not have the screening technology,” said Ajit Jadhav of NCATS. The center’s researchers can also help the companies polish the compounds to get them ready for further testing.Europe’s in the gameScientists recently formed the Joint European Compound Library with 321,000 compounds that originated in pharmaceutical companies’ libraries and plan to make 200,000 more compounds in the next four years. The library will be open to academics and biotech companies who otherwise would not have access to such a collection. “The emerging picture of a low chemical similarity between the independent screening libraries suggests that an efficient and cost-effective way to generate a highly diverse library would be to combine the libraries from multiple companies,” scientists wrote in February in Drug Discovery Today. “The combined chemical space explored by all the collections would be available and this would maximize the chances of hits against a novel biological target.”Some pharmaceutical companies are sharing selections, but don’t expect open accessThe compounds remain incredibly valuable to companies. “The library, the chemical compounds, are usually the cherished jewel of the company,” said Barbara Slusher, president of the Academic Drug Discovery Consortium and neuroscientist at Johns Hopkins University. “So they’re still quite reluctant to give that out in an unencumbered fashion.”center_img [email protected] General Assignment Reporter Andrew covers a range of topics, from addiction to public health to genetics. Andrew Joseph BusinessWhy drug makers share their prized compound libraries with competitors Here are six things you should know about compound libraries, and how different groups are trying to leverage them to improve drug discovery.The companies don’t worry about honing in on the same compoundCompanies want to protect their compounds: They spend a lot of money building and acquiring new ones, and they are intellectual property. So what if a compound turns out to be a hit for both Sanofi and AstraZeneca? First off, most hits don’t actually lead to new drugs. And even if both companies pursued the same chemicals, their scientists do so much work creating “lead compounds” and improving them that any resulting drugs would almost certainly not match. “Each of those is just a potential starting point for a drug discovery project,” said Stephen Frye, a former GlaxoSmithKline scientist who now directs the Center for Integrative Chemical Biology and Drug Discovery at the University of North Carolina at Chapel Hill. That’s why the trade between the two companies involves what is known as “precompetitive” research.advertisementlast_img read more

Super subs Devoy and Thornton strike late to fire Portlaoise CBS to U-16 Leinster final

first_img Pinterest By Alan Hartnett – 20th May 2019 Twitter The CBS made the perfect start when Conor Goode was dragged down for a penalty in the first minute and captain Josh Mulhall stepped up and smashed the ball into the top corner of the net.But the Dublin champions were no pushovers and wind assisted, they fired over the next four points via Eoin O hAodha, Oilibhear Birch and Somhairle Mac Conchubhair to take the lead.Portlaoise CBS keeper Conor Brown also had to be smart in the first half as he was forced into two fine saves to keep the Lucan men at bay. Portlaoise CBS U-16 Portlaoise CBS 3-9 Colaiste Cois Life (Dublin) 0-14Top Oil Leinster PP School U-16 Football ‘C’ Semi FinalSuper subs James Devoy and Aaron Thornton came off the bench and scored a goal each in the final three minutes as Portlaoise CBS came from behind to claim a Leinster final place.Stradbally’s Devoy, who is only in First Year, was making his first appearance of the season for the South Leinster champions and it was his goal which regained control of the game for the CBS before Thornton finished off Dublin champions Colaiste Cois Life from Lucan a couple of minutes later.This is a remarkable victory for Portlaoise CBS who went into the game without the likes of Cormac Dunne, DJ White, Ben Dempsey and Kevin Swayne – while their chances were further weakened ten minutes into the second half when Laois minor midfielder Conor Goode was shown a black card.But Paul Cahillane and Geoff Brennan’s side are made of stern stuff and along with the two subs already mentioned, The Heath’s Jack Reddy and Timahoe’s Daire McDonald also made big impacts when introduced. Previous articleMedals galore for Laois athletes as Leinster School’s Track & Field finalsNext articleRemember the Game: O’Dempsey’s claim U-16 football honours in 2009 Alan HartnettStradbally native Alan Hartnett is a graduate of Knockbeg College who has worked in the local and national media since 2008. Alan has a BA in Economics, Politics and Law and an MA in Journalism from DCU. His happiest moment was when Jody Dillon scored THAT goal in the Laois senior football final in 2016. Facebook Home Sport GAA Super subs Devoy and Thornton strike late to fire Portlaoise CBS to… SportGAAGaelic Football TAGSPortlaoise CBS Twitter Super subs Devoy and Thornton strike late to fire Portlaoise CBS to U-16 Leinster final Facebook Kelly and Farrell lead the way as St Joseph’s claim 2020 U-15 glory WhatsApp Two each from Paddy Hosey and Noah Fingleton regained the lead for Portlaoise CBS but a brace from Eoin O hAodha saw the sides level at 1-4 to 0-7 at the midpoint of the half.Portlaoise CBS almost had another goal through Hosey but his effort came back off the post and another point from him was all they would manage in the remainder of the half.Somhairle Mac Conchubhair and Eoin O hAodha split the posts for Colaiste Cois Life as they took a 0-9 to 1-5 lead into the interval.That margin was extended by Oilibhear Birch on the resumption of play but two points from James Connolly and another from Paddy Hosey had the CBS 1-8 to 0-10 ahead after 35 minutes.Eoin O hAodha levelled it again and although Connolly pushed the CBS back in front with 15 minutes to play, Colasite Cois Life got the next three points to go two ahead as we entered the closing three minutes and it was looking bleak for the CBS.First Year was on the field at this stage and when Paddy Hosey cut inside to find the youngster in front of goal, he turned onto his left side and shot low into the bottom corner.From the resulting kick-out, Josh Hogan-O’Brien, who worked tirelessly around midfield with Sam Birrane, Dan Daly and Josh Mulhall throughout, was fouled. James Connolly lobbed the ball in and it broke to sub Aaron Thornton who side-footed it to the net.Three minutes of injury time followed but the CBS held on and now reach the final stage.The lads now have a Leinster final to prepare for against the North Leinster champions which is likely to take place later this week.SCORERS – PORTLAOISE CBS: Paddy Hosey 0-4, James Connolly 0-3 (one free), James Devoy, Aaron Thornton and Josh Mulhall (penalty) 1-0 each, Noah Fingleton 0-2 COLAISTE COIS LIFE: Eoin O hAodha 0-5 (two frees), Oilibhear Birch (three frees) and Somhairle Mac Conchubhair 0-4 each, Alex Bairead 0-1PORTLAOISE CBS: Conor Brown (Portlaoise); Jamie Preston (Portlaoise), Jack Tobin (Portlaoise), Tommy Keegan (Emo); Marc Ramsbottom (Park-Ratheniska), Simon Fingleton (Park-Ratheniska), Gary Whelan (Portlaoise); Josh Mulhall (Park-Ratheniska), Sam Birrane (Portlaoise); Josh Hogan-O’Brien (Portlaoise), James Connolly (Park-Ratheniska), Dan Daly (The Heath); Noah Fingleton (Park-Ratheniska), Paddy Hosey (Emo), Conor Goode (Stradbally). Subs: Daire McDonald (Timahoe) for Preston (36), Aaron Thornton (The Heath) for Goode (40, black card), Jack Reddy (The Heath) for Whelan (43), James Devoy (Stradbally) for N Fingleton (45)COLAISTE COIS LIFE: Cathal O Duda; Sean Airneis, Daithi O Maitin, Rossa O Briain; Fionn O Giollain, Jamie O Laimhin, Cillian O Dochartaigh; Deiric O Cathail, Maitiu Mac Giolla Phoil; Dylan Mac Muiri, Somhairle Mac Conchubhair, Oilibhear Birch; Alex O Floinn, Eoin O hAodha, Alex BaireadSEE ALSO – Sadness in Emo as much-loved Eileen Kirwan passes away GAA Pinterest RELATED ARTICLESMORE FROM AUTHOR GAA WhatsApp GAA Here are all of Wednesday’s Laois GAA results 2020 U-15 ‘B’ glory for Ballyroan-Abbey following six point win over Killeshinlast_img read more

Imagine Broadband’s product offering to consumers

first_imgHome Sponsored Imagine Broadband’s product offering to consumers Sponsored RELATED ARTICLESMORE FROM AUTHOR GAA By LaoisToday Reporter – 4th July 2019 Here are all of Wednesday’s Laois GAA results Imagine Broadband’s product offering to consumers GAA TAGSImagine Broadband Superfast Broadband is now a reality for homes and businesses in County Laois thanks to Imagine.Laois is starting to see the benefits of the €300m investment Imagine is making in Superfast Broadband to cover over 1 million homes and businesses across Ireland within the next 18 months.While communities in the likes of Durrow, Borris-in-Ossory, Mountmellick, and the areas in between are already benefiting from Imagine’s new network build, a number of other areas have also been added, giving some 3000 plus properties in the county access to superfast broadband.Extensive coverage works have taken place in the county with the area’s from Killeshin to Clonaslee and Killenard to Rathdowney now also in coverage for Superfast broadband.Imagine Broadband’s Product offering to consumersUp to 150Mb Unlimited Home Broadband + Phone (Inc. All local, national and UK landline calls and 60 mins calls to Irish mobiles) Price €59.99 month Inc. VatBasic Business Product – Small Office/Home Office includes Unlimited Broadband + Phone and Calls (inc. All local, national and UK landline calls are 60 mins calls to Irish mobiles). Price €48.77 month ex. VatAbout 5G Fixed Broadband The latest generation of 4G Fixed broadband is capable of delivering 300Mbps services which far exceeds current user demand and has become an established alternative high-speed broadband solution. It faced the challenge of traditional fixed line companies marketing FTTH as the only solution that could meet future demand for high-speed broadband. Having failed to deliver, the arrival of the next generation of ‘Massive’ capacity 5G technology, capable of speeds well above 1Gbps and expected to exceed 10Gbps has changed all of that. 5G Fixed Broadband has become a game changer in the industry and significant challenger to traditional fixed line telecoms companies. Avoiding the significant cost and time to bring cables across poles and through underground ducts to homes, 5G technology allows providers to deploy high-speed broadband to large numbers of consumers in a short timeframe. 5G itself allows for extremely rapid download (up to 100 times faster than 4G) and upload speeds and decreased latency (i.e. the time it takes for devices to communicate with each other).5G Fixed Broadband has now become a mainstream alternative to FTTH to deliver future-proofed Next Generation high-speed broadband to homes and businesses. With major telecoms companies around the world, including Google Fibre, Verizon, AT&T and Sprint in the US already rolling out 5G Fixed Broadband as an alternative to FTTH and a quicker way to deliver high-speed broadband.Developed to provide the massive capacity needed to support the next generation of 5G mobile services including the internet of things, driverless cars, artificial intelligence and virtual reality, 5G Fixed Broadband is currently the primary business model and driver of commercial 5G infrastructure investment across the world.With the early release of 5G spectrum, Ireland will be one of the first countries in Europe to see the benefit from further innovative 5G services. The first 5G commercial launch of Imagines 5G Fixed Broadband Network will immediately deliver the benefit of high-speed broadband to homes and businesses.SEE ALSO – Rural Laois being connected to Imagine’s superfast broadband network Facebook Previous articleForest trails and incredible views in the Adventure Race at this year’s Folly Festival in CullohillNext articleIn Pictures: All smiles at Abbeyleix Cul Camp as Joe McDonagh Cup on show again LaoisToday Reporter Pinterest Facebook Pinterest Twitter WhatsApp WhatsApp GAA Twitter Kelly and Farrell lead the way as St Joseph’s claim 2020 U-15 glory 2020 U-15 ‘B’ glory for Ballyroan-Abbey following six point win over Killeshinlast_img read more

Healthy Buffs: 4 steps to staying healthy this flu season

first_imgShare Share via TwitterShare via FacebookShare via LinkedInShare via E-mail Viruses like the cold and flu can last 7-10 days, meaning symptoms like a stuffy nose, body aches, fatigue and a sore throat can stick around for a while. Since antibiotics typically don’t work for cold and flu viruses, it’s all about staying as healthy as possible, boosting the immune system, and finding symptom relief. So how do we do it?1. Get a flu shotYear after year the flu vaccine has been proven to be the most effective way to prevent the flu. Free flu shots are available to all CU Boulder students at specific walk-in hours on campus beginning Oct. 3 (just bring your Buff OneCard).Wardenburg Health Center:Monday-Friday, 10 a.m. to 12 p.m.Rec Center Wellness Suite/Fitwell Office:Mondays, 1 to 3 p.m.Tuesdays, 5 to 7 p.m.Wednesdays, 1 to 3 p.m.2. Protect yourself from germsWash your hands often—in the bathroom, before eating, after class, there’s no bad time! If warm water and soap aren’t available, alcohol-based hand sanitizer is a good alternative.3. Keep the immune system high-functioningOur immune systems are impacted by everything we do, from what we eat to our stress levels, so eating regular balanced meals, hydrating with lots of water, and sleeping 7-9 hours a night all help strengthen our bodies. When we’re well-rested, well-resourced and well-nourished, we’re more capable of fighting off an infection.4. Practice good health habitsWipe down communal surfaces like doorknobs and counters with disinfectant to kill any germs that may be around, cough and sneeze into your elbow or sleeve (but not hands, since hands touch everything), and stay home when you’re not feeling well. When we look out for each other, we all stay healthier in the long run.If you do find yourself not feeling well, try these tips: drink warm liquids like tea to soothe a sore throat, get extra rest to let your body recover, and use over-the-counter remedies as appropriate to find relief. Your body works hard to fight off these viruses and get you back into peak condition, so be kind to it!In fact, treat it to some cold care supplies on us: cough drops, tissues, tea, honey sticks, gargling salt, and hand sanitizer are all available free to CU Boulder students in the Health Promotion Resource Center located in UMC 411.  More health tips Published: Sept. 28, 2016 center_img Categories:Healthy BuffsCampus Communitylast_img read more

Crime is Jamaica’s Biggest Problem – Minister Bunting

first_imgStory HighlightsNational Security Minister, Hon. Peter Bunting, says that in spite of achievements made last year, crime and corruption remains the main obstacles to rapid growth and development in Jamaica.Speaking at the launch of the Jamaica Employers’ Federation’s (JEF) 31st annual business and workplace convention and expo, held at the Knutsford Court hotel in New Kingston on January 22, the Minister said increased investment in the fight against crime and violence would augur well for the country’s economy.“The truth of the matter is… investment in national security is an investment in Jamaica’s economic growth and development,” he stated. Advertisements RelatedCrime is Jamaica’s Biggest Problem – Minister Bunting FacebookTwitterWhatsAppEmail RelatedCrime is Jamaica’s Biggest Problem – Minister Buntingcenter_img National Security Minister, Hon. Peter Bunting, says that in spite of achievements made last year, crime and corruption remains the main obstacles to rapid growth and development in Jamaica.Speaking at the launch of the Jamaica Employers’ Federation’s (JEF) 31st annual business and workplace convention and expo, held at the Knutsford Court hotel in New Kingston on January 22, the Minister said increased investment in the fight against crime and violence would augur well for the country’s economy.“The truth of the matter is… investment in national security is an investment in Jamaica’s economic growth and development,” he stated.The Security Minister pointed out that a number of studies conducted by the World Bank and various other multilateral organizations show that crime continues to be Jamaica’s biggest problem.He pointed to a recent study conducted by researchers at the University of the West Indies, which showed that for the last four decades if Jamaica had a normal crime rate, the country’s economy would be between three and 10 times the size it is now, in terms of Gross Development Product (GDP).“And that doesn’t even take into account the pain and suffering and grief and misery that this has caused,” he stated.Mr. Bunting also said that the country is currently ranked 97 on the World Economic Forum’s (WEF) competitiveness index, slipping 30 places in the last five years.“This has an impact on investor confidence and I don’t need to tell you about the impact it has on the cost of doing business in Jamaica and more generally, just eroding the quality of life,” he stated.The Minister reiterated plans to further reduce all crimes by double digits for 2013. Jamaica recorded a seven per cent reduction in murders, shootings and other serious crimes in 2012, to register the lowest number of offences the country has seen in the last nine years.Mr. Bunting informed that among the measures he will be implementing over the next five years to achieve his target, is an increase in the number of “boots on the ground”.He noted that the Ministry is looking to recruit an additional 5,000 soldiers and police officers to further boost the crime fighting capacity of the Jamaica Defence Force (JDF) and the Jamaica Constabulary Force (JCF).He also said the security forces would need an additional 500 vehicles, every year, for the next four years to improve their mobility. Crime is Jamaica’s Biggest Problem – Minister Bunting National SecurityJanuary 23, 2013Written by: Athaliah Reynolds-Baker RelatedCrime is Jamaica’s Biggest Problem – Minister Buntinglast_img read more

Jamaica Cops EU Women Empowerment Award

first_imgRelatedTime Ripe For Media To Set Up Complaints Council – Minister Falconer Jamaica has been honoured by the European Union (EU) for its role in the empowerment of women, in particular for closing the gender gap in terms of women, who work in public administration.A beaming Prime Minister, the Most Hon. Portia Simpson Miller, accepted the award on behalf of Jamaica, during a high profile gala and awards dinner hosted on Wednesday, November 27, by the Women In Parliaments (WIP) Global Forum, at the Royal Museum Of Art and History in Brussels, Belgium.The award is given to a country that has achieved a remarkable level of representation by women in the legislature, as senior officials and managers.“I find it gratifying that the European Union has recognized Jamaica’s achievement in the area of gender equality. I accept with a spirit of humility on behalf of the women of Jamaica, who I represent, and to whom I pay tribute this evening,” she said.Mrs. Simpson Miller noted that many Jamaican women continue to make their mark in their various spheres of endeavors despite the odds. She thanked the European Parliament and WIPs Forum for their initiative in providing an avenue for discussion on women’s leadership, noting that the experience has been enriching.“Let us therefore vow to make gender equality a reality in this generation,” she urged the participants.The Prime Minister urged the young women in the audience to pursue their dream and not to be daunted by obstacles. “I want to say to the young women, be strong, be courageous. There are some who will say that politics is not a good thing, but if it is not good and good people do not get involved, it will remain bad, so we need to be engaged and involved,” she said to loud cheers from the packed room.She stated that politics is an area where women can influence change in policy. Mrs. Simpson Miller urged the young women to use the successful women in the room as examples, telling them “you can make a contribution to your country and to humanity.”She said her greatest joy is serving.President of the EU- Latin American and Caribbean (LAC) Foundation, Benita Ferrero-Waldner, who made the presentation to the Prime Minister, noted that 28 per cent of the country’s mayors and 56 per cent of Permanent Secretaries are females. In addition females dominate top positions such as Chief Justice, accountant general and other top public posts.The WIP awards are based on the rankings of the World Economic Forum’s Global Gender Gap Report, and are awarded to countries for leadership in closing the gender gap.The gender gap report assesses 135 countries, representing more than 93 per cent of the world’s population on how well resources and opportunities are divided among male and female populations. It measures the size of the gender gap in four areas: economic participation and opportunity – salaries, participation and highly skilled employment; education – access to basic and higher levels of education; political empowerment – representation in decision making structures; health and survival – life expectancy and sex ratio.Other winners in the category of political empowerment are Rwanda, for Women in Parliament; and Ireland for number of years with Female Head of State. Iceland was named the Global Winner in Closing the Gender Gap. Jamaica Cops EU Women Empowerment Award Office of the Prime MinisterNovember 28, 2013Written by: Andrea Braham Story HighlightsJamaica has been honoured by the European Union (EU) for its role in the empowerment of women.The award is given to a country that has achieved a remarkable level of representation by women in the legislature.The Prime Minister urged the young women in the audience to pursue their dream. FacebookTwitterWhatsAppEmail Advertisementscenter_img Jamaica Cops EU Women Empowerment AwardJIS News | Presented by: PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQualityundefinedSpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreenPlay RelatedMinister Falconer Clarifies ‘Guidelines’ to Media Photo: JIS PhotographerPrime Minister, the Most Hon. Portia Simpson Miller (right), proudly holds the award given to Jamaica for bridging the gender gap in terms of women in public administration, awarded by the European Union. The presentation was made during a high profile gala and awards dinner hosted by the Women In Parliaments (WIP) Global Forum, on November 27, at the Royal Museum Of Art and History in Brussels, Belgium. Speaker of the Chamber of Deputies of Rwanda, Donatille Mukabalisa (left), accepted the award on behalf of her country for Women in Parliament; while Speaker of the Senate in Ireland, Paddy Burke, accepted the award for his country, which was recognized for the number of years with Female Head of State. RelatedPM Says Lack of Funding Keeping Women Out of Politicslast_img read more

Marijuana entrepreneurs hope to see green at pitch event

first_imgHomeBusinessMarijuana entrepreneurs hope to see green at pitch event Aug. 20, 2018 at 5:01 amBusinessFeaturedNewsMarijuana entrepreneurs hope to see green at pitch eventKate Cagle3 years ago420MarijuanaweedFile photo Investors looking to cash in on California’s burgeoning marijuana industry can learn about local start-ups this week at a pitch competition at Expert Dojo inside Santa Monica Place on Wednesday.“This is a booming, growing economy,” said Peter Vogel, CEO of Leafwire, the company behind the event. “Like any industry, getting in at the beginning rather than the middle or the end, you’re more likely to see bigger, more exciting returns.”Despite banking restrictions and other complications related to dealing with a product that is still illegal at the Federal level, cannabis-related companies secured more than $1.5 billion in the first quarter of 2018, according to New Frontier Data. Vogel said having a good lawyer is key to participating in the marijuana market.He said hesitant investors can start with one of 45,000 ancillary businesses that don’t directly deal with marijuana, but supply payment processing software, media, human resources, or compliance aspects of the industry.“For new investors, there’s less regulation and less exposure investing in those companies,” Vogel said. “It’s an easier entry point.”Nearly 30 states and the District of Columbia have legalized marijuana for either medicinal or recreational use. Leafwire estimates the legal industry is already worth $9 billion. Given the illegal nature (and stigma) surrounding the drug, many entrepreneurs are inexperienced and need guidance to scale their ideas and secure funding.In this state, second quarter tax revenue from cannabis totaled $74 million, according to new data from the California Department of Tax and Fee Administration (CDTFA). That amount does not include additional taxes imposed by cities. Santa Monica only recently permitted medical marijuana dispensaries in the city limits and does not currently allow recreational stores.Vogel’s event here is just one of a national cash call to get more investor money into the industry. He’s hosting similar “Shark Tank” inspired events in Miami, Oakland and Boston this fall. During the Future of Cannabis Pitch Competition, six companies will make three-minute pitches to a panel of judges. The panel of investors will award the winner with a $10,000 PR distribution from AxisWire and tickets to the High Times Cannabis Cup, the industry’s top competition for growers.Tickets are still available for the event at lajointventures.com and cost $19. The program will run from 6 p.m. – 9 p.m. at Expert Dojo, 395 Santa Monica Place on Wednesday, August [email protected] :420Marijuanaweedshare on Facebookshare on Twitteradd a commentKate CagleSenior ReporterSenior reporter for the Santa Monica Daily Pressview all postsLetters to the EditorCity Manager envisions a larger pedestrian zone for DowntownYou Might Also LikeFeaturedNewsBobadilla rejects Santa Monica City Manager positionMatthew Hall9 hours agoFeaturedNewsDowntown grocery to become mixed use developmenteditor20 hours agoNewsBruised but unbowed, meme stock investors are back for moreAssociated Press20 hours agoNewsWedding boom is on in the US as vendors scramble to keep upAssociated Press20 hours agoNewsCouncil picks new City ManagerBrennon Dixson20 hours agoFeaturedNewsProtesting parents and Snapchat remain in disagreement over child protection policiesClara Harter20 hours agolast_img read more

Berners-Lee backs ‘affordable internet’ initiative for developing markets

first_img Tags Author Ken has been part of the MWC Mobile World Daily editorial team for the last three years, and is now contributing regularly to Mobile World Live. He has been a telecoms journalist for over 15 years, which includes eight…More Read more A4AI chair warns on unrealistic UN 2020 goal Interview: A4AI Chair Ken Wieland M360 2016 Africa Article Internet pioneer Sir Tim Berners-Lee is backing the Alliance for Affordable Internet (A4AI), a group of private and public companies pushing for regulatory reform to drive down internet access prices in developing countries.“The reason for the alliance is simple – the majority of the world’s people are still not online, usually because they can’t afford to be,” said Berners-Lee.He gives the example of Mozambique where a recent study showed that using just 1GB of data can cost over two months’ wages for the average citizen.“The result of high prices is a widening digital divide that slows progress in vital areas such as health, education and science,” he added. “Yet with the advent of affordable smartphones, new undersea cables and innovations in wireless spectrum usage, there is simply no good reason for the digital divide to continue.”By advocating open, competitive and innovative broadband markets, A4AI aims to help access prices fall below 5 per cent of monthly income worldwide, a target set by the UN Broadband Commission.According to the International Telecommunications Union, reaching this goal would help connect two-thirds of the world’s population currently not connected to the internet.A4AI announced a range of plans at the Commonwealth Telecommunications Organisation’s Annual Forum in Abuja, Nigeria, on 7 October.They include in-country engagements with three to four states by the end of 2013, expanding to at least twelve countries by the end of 2015.Key policy areas to drive prices down include “allowing innovative allocation of spectrum, promoting infrastructure sharing, and increasing transparency and public participation in regulatory decisions”.A4AI says it will produce an annual ‘Affordability Report’, with the first edition being unveiled in December 2013.The alliance was initiated by the World Wide Web Foundation (founded by Berners-Lee). It is sponsored by Google, Omidyar Network (a philanthropic investment firm), the UK Department for International Development, and the United States Agency for International Development.The intenet.org initiative – whose founding members are Facebook, Ericsson, MediaTek, Nokia, Opera, Qualcomm and Samsung – was launched in August.Its aim is to bring connectivity to the five billion people around the world currently without access to the internet by developing and adopting technologies that makes mobile connectivity more affordable.center_img Previous ArticlePrivate bank eyes 50% stake in Tele2 Russia – reportNext ArticleHTC facing “most challenging” quarter AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 07 OCT 2013 A4AIBerners-Lee Related A4AI chair lauds OTT players for internet investment but snubs Facebook Basics Home Berners-Lee backs ‘affordable internet’ initiative for developing marketslast_img read more

PhD Research Fellow in Human Geography at University of Oslo

first_imgPhD Research Fellow in Human Geography at University of Oslo July 17, 2014 Published by lenka 2021 DRAPER HILLS SUMMER FELLOWS PROGRAM Gender Equality Research Fellowship → Deadline: 15 August 2014Open to: graduates with master’s degree in human geographyScholarship: salary in pay grade 50-57 (NOK 416 600 – 468 400 per annum)DescriptionThere is a vacant position at the Department of Sociology and Human Geography for a research fellow in human geography. The position is for a period of up to 4 years with 25 % compulsory work (primarily teaching). The Department Human Geography is divided into two core areas. Research fellows should have research interests within one or more of these areas:1. Development in third-world countries, politics, and the environment;2. Urban and regional development.EligibilityApplicants for the position of research fellow must have a master’s degree/second-level degree in human geography. The master’s thesis must has been submitted before the application deadline.ScholarshipSalary in pay grade 50-57 (NOK 416 600 – 468 400 per annum), depending on competence;A pleasant working environment;A good pension scheme through the Norwegian Public Service Pension Fund;Good welfare benefits.ApplicationThe electronic application should include:A letter of application;Project proposal (5-10 pages) which should include the topic, relevant theory and methods and a work plan. If the project requires field work or data collection, costs must be calculated and presented in a budget;CV with full summary of education, practice and academic work. The period of enrollment (admission-completion) in the master’s study programme must be specified;Copies of certificates and references;Master’s thesis – please note that there is no separate prompt for uploading your thesis in the electronic application. Your thesis must therefore be uploaded as “attachment”;Complete list of publications and any academic work.The hiring process will include an interview. In addition to an overall evaluation of the applicant’s grades, particular emphasis will be placed on the quality of the project proposal and the master’s thesis.For further information, please visit the official website. The Joint Japan/World Bank Graduate Scholarship Program 2021 +1 LinkedIn 0 2021 Senesh Fellowshipcenter_img ← International Conference ‘What Divides Europe?’ in Georgia Similar Stories Pocket Leave a Reply Cancel ReplyYou must be logged in to post a comment. Share 0 Reddit Tweetlast_img read more

Navy to relieve captain of aircraft carrier over leak of letter to leadership: Source

first_imgUS Navy(NEW YORK) — The captain of the aircraft carrier USS Theodore Roosevelt, is being relieved of duty over the leak of his letter which requested that most of his ship’s crew of 5,000 be taken off the ship to prevent the spread of novel coronavirus.Thomas Modly, the acting secretary of the Navy, said Thursday that he couldn’t say if Capt. Brett Crozier leaked the letter himself, but noted that the letter was emailed to 20-30 people, which provided an opportunity for the letter to be leaked.Crozier wrote the letter to Navy leadership and Wednesday they said he would not be disciplined for having expressed his concerns through the chain of command.However, Modly left the door open for discipline if it was proven that Crozier had leaked the letter himself.Crozier’s letter created a firestorm of controversy after it was leaked to the San Francisco Chronicle.In the letter, Crozier also asked that the sailors be moved from communal facilities on Guam to individual housing to conform with coronavirus safety guidelines established by the Centers for Disease Control and Prevention (CDC).On Wednesday, the Navy announced its plans to move 2,700 sailors from the USS Theodore Roosevelt to quarters in Guam as the number of sailors testing positive for the novel coronavirus had increased to 93. Copyright © 2020, ABC Audio. All rights reserved.last_img read more