Scientists explain underlying cause of unhealthy brain aging

first_imgShare Share on Twitter Doctors commonly recommend patients increase their intake of calcium as a means of combating osteoporosis for aging bones.But calcium also plays an essential role in the neurological functioning of the brain, where it must be tightly regulated and not rise to excessive levels. A signaling molecule, calcium enables learning, cognition and the retention of memories. Calcium also facilitates communication among nerve cells and transports molecules to the many branches of the nerve cell.Building on scientific evidence implicating disturbed calcium regulation in brain aging accumulated through the past 30 years, a research team in the University of Kentucky Department of Pharmacology and Nutritional Sciences led by principal investigator Philip Landfield has found a connection between unhealthy brain aging and a protein responsible for regulating calcium at the molecular level, called FKBP1b. The team’s groundbreaking research, which was published July 29 in the Journal of Neuroscience, identifies a molecular mechanism occurring within the cell that appears to cause unhealthy brain aging. The research suggests the absence or addition of the FKBP1b protein is a strong determinant of functioning in the hippocampus region, a part of the brain responsible for cognition and memory retention. LinkedIn Unhealthy brain aging is defined as a reduction in brain function resulting in memory impairment. Excess calcium in brain cells appears responsible for important aspects of unhealthy brain aging, and may also increase susceptibility to diseases such as Alzheimer’s, ALS, Parkinson’s and vascular dementia. Until now, the precise molecular cause of the disturbed calcium regulation in brain aging has remained unknown to scientists.After learning about the FKBP1b protein’s recently uncovered role in the heart, the UK researchers wondered whether FKBP1b in the hippocampus region declines with brain aging. They then found evidence of reduced FKBP1b gene expression with aging in the hippocampus. This discovery prompted the researchers at the University of Kentucky to test whether boosting FKBP1b in the hippocampus region could reverse or prevent brain aging linked to memory loss.“It is well-recognized that normal aging is the greatest risk factor for Alzheimer’s disease, but nobody knows why,” Landfield, a professor in the department, said. “It’s possible this (decreased FKBP1b) is the missing link.”The team used an advanced gene therapy approach to inject harmless virus particles, which created additional copies of the FKBP1b protein, into the hippocampus of aging rats. The memory abilities of three groups of rats were tested two months after the injections. One group of young rats received a control injection, one group of aged rats received a control injection and one aged group received an injection of the FKBP1b-producing virus particles. The aged group with raised levels of FKBP1b showed restored calcium regulation and dramatically improved cognitive function, allowing them to perform the memory task as well as or better than the young rats. In addition, the researchers have repeated and extended the results in a subsequent study being prepared for publication.The research provides evidence the manifestations of brain aging can be reversed, and cognition and memory function restored, by altering levels of FKBP1b. This finding is also significant for Alzheimer’s patients as the researchers found a decline in the FKBP1b protein in the hippocampus of people who had early-stage Alzheimer’s. The research has implications for preventing brain aging associated with the progression of Alzheimer’s, and opens the door for pharmaceutical development aimed at sustaining levels of FKBP1b and keeping calcium in check.“We showed FKBP1b is a master regulator of calcium in brain cells, and when we restore it, it restores the regulation of calcium and dramatically improves learning in the aged animals,” Landfield said. “In all my years of doing research, I’ve never seen a compound this effective; it’s rare that tests of a hypothesis satisfy each of the criteria that have to be met.”The UK team is the only known group studying FKBP1b in brain aging. As a next step, the researchers are interested in investigating why FKBP1b declines with age. Landfield said there is promise to regulate the protein through Vitamin D, which is known to restore calcium deficiencies in other cells.The research was supported by a grant from the National Institute on Aging and was published recently in the Journal of Neuroscience.center_img Email Share on Facebook Pinterestlast_img read more

Kirtland Increases Health Protection Condition

first_imgKIRTLAND AIR FORCE BASE. – Kirtland has raised its Health Protection Condition (HPCON) level to B-plus in response to the spread of COVID-19.The decision to implement a higher HPCON was taken to stay in step with the Air Force and state and local authorities.There are no cases of COVID-19 on Kirtland AFB.The Installation Commander, Col. David S. Miller, has directed the elevation of the condition level to align with existing precautionary measures, and education of base personnel in preventing a potential widespread outbreak.The HPCON B-Plus increase implements base measures that defines heightened exposure risk. The new recommendations include increasing the measures of HPCON A: vigorous hand-washing, self-monitoring for symptoms and self-isolating, and disinfecting frequently touched surfaces. HPCON B expands these measures to include: strict hygiene, self-isolation if exposed even if not symptomatic, careful cleaning of common-use items/areas, and staying away from large gatherings.The new condition level also directs maximum use of telework for non-essential personnel, to limit in-person meetings, as well as restriction of movement for individuals who have recently traveled to impacted areas. For Team Kirtland mission partners, the implementation of the measures will be decided by their respective commanders.For the latest information on COVID-19, see https://www.cdc.gov/coronavirus. For Kirtland specific information and updates, see the Kirtland Public Web site at www.kirtland.af.mil and download the Kirtland app.last_img read more

Praxair reveals 2020 Sustainable Development Targets

first_imgSubscribe Get instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270.last_img

ROMAR targets Caspian region

first_imgOilfield service company ROMAR International has appointed STEP Oiltools as its agent in the Caspian region, in a two year agreement.STEP Oiltools already promotes ROMAR’s range of magnetic separation products in Norway, South East Asia and the Middle East in a highly successful arrangement between the two companies.As well as the new deal for the Caspian, a result of continued success in South East Asia, ROMAR has increased its presence in the region to cover Malaysia, as part of the agreement with STEP Oiltools. Last month, a swarf handling contract worth a six figure sum with a major oil and gas operator was secured for ROMAR and work will commence in Q3 2014.ROMAR’s core business activities revolve around its innovative designs using magnetic separation technologies which provide value-added solutions for its clients. The company has developed a range of products and services tailored to suit various demands and applications across the offshore oil and gas markets worldwide.The latest deal will involve ROMAR’s products being introduced to the Caspian region, targeting Russia, Azerbaijan, Kazakhstan and Iran.ROMAR International Commercial Director Robbie Gray said: “International work now accounts for 35% of our business and we are confident this agreement with STEP Oiltools will dramatically increase our presence in the Caspian region. Working with STEP Oiltools these past two years has been exceptionally beneficial; together, we have secured a number of global contracts which have significantly increased company turnover.“As demand for our products continues to rise in South East Asia, Malaysia was identified as a key region for our international business strategy moving forward and are happy that our agreement with STEP Oiltools now covers Malaysia. Having already secured a contract for this year is very promising and confirms the demand for our products.“Exceeding our company targets for the first half of 2014 is in part due to our strategic relationship with STEP Oiltools and we look forward to continuing this valuable affiliation.”Alan Steedman, Vice President Europe STEP Oiltools, said: “ROMAR’s product line is a proving a valuable addition to our product offering. Due to the predicted increase of well plugging and abandonment in the Caspian region in the next few years, we are sure there will be a strong demand for ROMAR’s products in achieving reliable and efficient means of disposing swarf waste, both on and offshore.”“Our latest agreement with ROMAR is a testament to, not only, the strength of our relationship, but our considerable progress as a team. Over the past two years we have worked hard with ROMAR to significantly expand into its target locations, including South East Asia and the Middle East, and we were delighted to secure a contract in Malaysia, with an oil and gas operator, earlier this year.”Since 2001 the company has grown in size and currently provides products in many oilfield industry provinces including the UK and Norwegian North Sea, West Africa, Gulf of Mexico, South East Asia, the Middle East and South America. Its success is reinforced by its ability to set up strategic partnerships in regions where ROMAR’s products will be well utilised. [mappress]Source: Romar, May 22, 2014last_img read more

Platform installed on Jumbo Javelin to deliver TPs

first_imgThe platform, manufactured by Delft-based Amplemann, will allow the ship to install transition pieces (TP) for wind turbines.The ship will be able to carry nine TPs, each weighing around 285 tonnes, stowed vertically in the hold. Jumbo Javelin will position next to the monopile of the wind turbine foundation to lift the TP from the hold, onto the monopile and adjust it to required horizontal level.According to a statement by Jumbo, this will be the first time that TPs will be placed on monopiles from a free-floating ship. The advantage of using a heavy lift ship is that it allows the transport of the TPs, fast transit to the site and the installation on the monopilelast_img

Spain calls for H

first_imgThe service to Spain will commence with the sailing of Höegh Seoul this month.The increased Spanish offering will be served by PCTC vessels, able to carry automobiles, construction and agricultural equipment, boats, and a wide range of project and breakbulk cargoes.  www.hoeghautoliners.comwww.jaxport.comlast_img

Valencia funds airport link

first_imgTHEREGIONAL government of Valencia is to spend Pts8bn on extending FGV metro Line 3 from Mislata to Manises Airport. The new tunnel section is expected to open by 2005 at the latest, putting the airport within 15min of the city centre.A new department has been created within FGV to manage investment by the regional government. This will also take on any debt incurred by rail projects, such as metro Line 2 and Line 5 under construction between Alameda and Parque Ayora.last_img

European Commission must act to liberalise rail freight

first_imgThe European Union must enforce the spirit of its First Railway Package if the revitalisation of rail freight is to be achieved, argues Tony Berkeley, Chairman of the Rail Freight Group UK and a Board Member of the European Rail Freight Customer PlatformTHERE WAS a chilling reminder at the CEE Rail conference in Budapest (RG 11.06 p697) of just how far the European goal of open access and on-rail competition for freight traffic remains from reality.The European Commission and member states have all signed up to the First Railway Package, and should have implemented the regulations at least two years ago. The Commission has produced evidence that competition leads to growth, better customer service and more competitive prices, as we have seen in the UK already.But as well as the problems in the CEE countries mentioned last month, some states in ‘old Europe’ seem to be making little progress. In a number of countries, notably France, there is a serious lack of independence of the timetabling organisation from the train operators. With incumbent operators running the timetable, they inevitably give themselves the best slots as well as getting prior knowledge of their competitors’ plans.Some member states still structure access charges with a large lump sum and a lower mileage charge, which again favours operators who can spread the lump sum over a larger number of trains. Again and again we heard about problems of new entrants crossing borders, where restrictive practices should have been abolished so that operators can be treated equally. There is an ongoing problem over access to terminals and marshalling yards. Whereas some intermodal terminals have been open-access since they were developed, this is not the case generally for wagonload traffic, which is why the First Railway Package requires such terminals to be open-access. Too many incumbent operators are scrapping wagons or locomotives, rather than selling them to potential competitors. Since these will have been purchased with public money or state aid, it could be argued that such disposal is an abuse of this provision. It demonstrates a serious failure by the member states to encourage liberalisation in a positive manner.And finally, a court in Germany has recently ruled that monopoly provider DB can supply electric traction power and diesel fuel to its competitors at any price it wants, without having to declare the price it charges to itself. How transparent is that?Rail freight customers remain deeply concerned. The current situation is fragile. New entrants face multiple problems, often caused by lack of fair implementation or application of the Directives. Few have the resources to fight endless procedural battles, or to start legal action against an incumbent operator able to call on government support. I therefore believe that it is essential that the Commission takes urgent action to require member states’ governments to deliver and implement the full agenda, and deploys sufficient staff to initiate infringement or anti-competitive actions against offending member states. It is not sufficient to pass EU legislation and then sit back and hope that everything will happen as planned. A competitive marketplace requires nurturing and encouraging in detail as well as in policy, and it needs to be done proactively. Without the private sector demonstrating quality and creativity, there is every prospect of rail freight dying across Europe. With the private sector setting an example, incumbent railways will also be encouraged to change their ways, so that the rail industry and society alike will benefit.last_img read more

DR Congo records five new cases of Ebola: WHO

first_imgFour new Ebola cases confirmed in DR Congo Ebola outbreak cases hit 1000 in DR Congo Worker of center for disease control describing effects of ebola virus mutation Ebola healthcare workers in the Eastern Congolese town of Beni in the Democratic Republic of Congo, October 8, 2019. REUTERS/Zohra Bensemra/File PhotoFive new Ebola infections have been recorded in eastern Congo since last week in a new flare-up just as the government was about to declare an end to the deadly epidemic, the World Health Organization said on Friday.Small outbreaks or one-off transmissions are common towards the end of an epidemic. Health workers are often able to prevent the virus from spreading out of control by quarantining and vaccinating contacts of new cases.On April 9 a 26-year-old electrician died of the hemorrhagic fever in the eastern town of Beni two days before the Democratic Republic of Congo planned to declare an end to the Ebola outbreak, which has killed more than 2,200 people since its onset in August 2018.The two newest cases were a 43-year-old woman and a 28-year-old motorbike-taxi driver who had brought the electrician to the hospital, according to Boubacar Diallo, deputy incident manager for the WHO’s Ebola response operation.It was unclear if the woman was linked to the other cases in a new chain of transmission, he said, but the new cases forced Congo’s national government to shelve its declaration of an end to the epidemic.Two new vaccines have had a major impact in containing Ebola, but public mistrust and militia attacks have prevented health workers from reaching some areas hit by the virus.Demonstrators blocked roads in Beni with rocks on Thursday morning, protesting over the authorities’ handling of the latest Ebola flare-up and demanding all Ebola test results be verified by laboratories in eastern Congo’s main city Goma and in the capital Kinshasa in the west of the vast Central African nation.Health teams were delayed by the protesters but eventually able to resume their work tracing those who came into contact with those newly infected by Ebola, Diallo said. Police said they arrested four people.Late last year deadly attacks on health centres in and around Beni forced aid groups to suspend operations and withdraw staff from the last strongholds of the epidemic.Congo, one of the world’s poorest countries where most people have scant access to modern health care, has also reported 287 cases of the new coronavirus and 23 deaths from the global pandemic.Relatedcenter_img Ebola Cases Reduce in Guinealast_img read more

POLICE APPEAL FOR WITNESSES TO FATAL ROAD CRASH – A702, ELVANFOOT

first_imgAddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to LinkedInLinkedInLinkedInPolice Scotland is appealing for information following a fatal road crash on Saturday 12 May 2018 in Elvanfoot, South Lanarkshire.Around 1105 hrs, a motorcyclist was travelling southbound on the A702 on his black BMW R1200 motorbike when it appears to have lost control, causing the motorcyclist to be thrown to the ground. The 51 year old man sustained serious injuries and was pronounced dead at the scene.The deceased can be named as Michael Smail from Auldgirth in Dumfries and Galloway.Several passing motorists stopped to assist at the location of the incident.The road was closed for several hours as officers conducted enquiries at the scene.An investigation is underway to establish the exact circumstances of the incident and officers are appealing for anyone who may have been travelling on the road around the time of the incident to contact them with any information. In particular, if anyone has any dash cam footage, please pass the footage to officers as it could assist in their enquiries.Anyone with information is asked to call Road Policing Officers at Motherwell Police Station via 101, quoting incident number 1527 of 12 May 2018.last_img read more